Nothing closed except the GSMP and I believe the Cherohala Skyway was closed but there is a report it has been reopened, at least on the NC side. Some information:
While the recommendation is that you stay at home and stay safe, you may have reason to travel through the NC Smokies. Here’s what you need to know.
www.visitsmokies.org
One mountain county blocked visitors in its battle against coronavirus. The checkpoints came with some criticism, but they have proven successful. Now, those barriers have been removed. WLOS. In late March, Graham County leaders put up checkpoints, stopping in-bound traffic from North Carolina...
my40.tv
As for the main travel roads, state roads, county roads, etc, no closures. Gas stations are open as well as some fast food places (drive through only). The Governor has released orders for orderly, planned return to normal starting this week. Knoxville and Knox County have their own plans so some restaurants you were planning to visit may still be closed in the dining area but open for pick-up/curb side.
There have been a LOT of riders over the past couple of weeks on the sunny days. I live just off one leg of the Devil's Triangle and there has been plenty of motorcycle traffic. If you are staying with friends, you may want to verify that their work location is good with them having out of state company. There are a lot of state/federal employers here in the area and restrictions for visiting and having friends visit can put a damper on them reporting to work.
Otherwise, it's a great time of year for riding in East TN. Have a good, safe visit.