Lot's of folks have. A better tune is the biggest reason as well as some installing 558 and 585 cams. I usually do not touch the ride modes since it covers the bases well with Touring, Standard, and Sport modes.
I probably should have mentioned that my question was related to my plans to install the high flow air performance air intake. I was going to just do PV3, but decided to use the card from Indian and took it to a shop to have it updated. Wow - I will be staying with this for a while. The Indian calibration that comes with it is pretty wild and a lot of fun.